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PUBLICATIONS

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  • Lenka et al., Specific interactions with phospho-Ubls and allosteric conformational changes regulate the E3 ligase activity of Parkin (https://www.biorxiv.org/content/10.1101/2023.11.21.568018v4)

  • Lenka et al., Additional feedforward mechanism of Parkin activation via binding of phospho-UBL and RING0 in trans (https://www.researchsquare.com/article/rs-2859540/v4)

  • Sahoo P, Lenka DR, Batabyal M, Pain PK, Kumar S, Manna D, Kumar A Detailed Insights into the Inhibitory Mechanism of New Ebselen Derivatives against Main Protease (Mpro) of Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2)  (2023) ACS Pharmacol. Transl. Sci. 2023, 6, 1, 171–180 (Published on the cover page)

  • Kakade P,......., Kumar A, et al., Mapping of a N-terminal α-helix domain required for human PINK1 stabilization, Serine228 autophosphorylation and activation in cells (2022),  Open Biol. https://doi.org/10.1098/rsob.210264

  • Mishra T, Dalavi R, Joshi G, Kumar A, Pandey P, Shukla S, Mishra RK, Chande A. SARS-CoV-2 spike E156G/Δ157-158 mutations contribute to increased infectivity and immune escape (2022), Life Sci Alliance.

  • Mishra T, Sreepadmanabh M, Ramdas P, Sahu AK, Kumar A, Chande A. SARS CoV-2 Nucleoprotein Enhances the Infectivity of Lentiviral Spike Particles (2021), Frontiers in Cellular and Infection Microbiology.

  • McWilliams TG, Barini E, Pohjolan-Pirhonen R, Brooks SP, Singh F, Burel S, Balk K, Kumar A et al., Phosphorylation of Parkin at serine 65 is essential for its activation in vivo (2018) Open Biol. 8: 180108

  • Kumar A et al., Structure of PINK1 and mechanisms of Parkinson’s disease associated mutations (2017) eLife Oct 5;6. pii: e29985. doi: 10.7554/eLife.2998

  • Kumar A et al., Parkin–phosphoubiquitin complex reveals cryptic ubiquitin-binding site required for RBR ligase activity (2017) Nat Struct Mol Biol. May;24(5):475-483. doi: 10.1038/nsmb.3400.

  • Khan SH, Kumar A, et al., Structural and thermodynamic characterisation of L94F mutant of horse cytochrome c (2016). Int J Biol Macromol. 92:202-212.

  • Kumar, A. et al., Disruption of the autoinhibited state primes the E3 ligase parkin for activation and catalysis (2015) EMBO J. doi:10.15252/embj.201592337 (Coverpage & news and views)

  • Kazlauskaite A, Martínez-Torres RJ, Wilkie S, Kumar A, et al., (2015) Binding to serine 65-phosphorylated ubiquitin primes Parkin for optimal PINK1-dependent phosphorylation and activation. EMBO Rep. e201540352

  • Kumar A, et al., (2014) Crystal structure of Rv2372c identifies a RsmE- like methyltransferase from M. tuberculosis. Acta Crystallographica Section D. 70: 821-32

  • Kumar A, et al., (2013). Crystal structure of Rv3717 reveals a novel amidase from Mycobacterium tuberculosis. Acta Crystallographica Section D. 69: 2543-2554

  • Kumar A, et al., (2011). Structural and functional characterization of Rv2966c protein reveals an RsmD-like methyltransferase from Mycobacterium tuberculosis and the role of Its N-terminal domain in target recognition. J Biol Chem. 286:19652-61.

  • Kumar N, Taneja KK, Kumar A, et al., (2010). Novel mutation in ATP-binding domain of ABCD1 gene inadrenoleukodystrophy. J Genet 89: 473-7.

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